Basic Molecular Information

Basic Information

DICL ID
DICL_CP_0313005
PubChem CID
Molecular Formula
C10H7Cl2N
Molecular Weight
212.079 g/mol
Synonyms/Alias
[CHEMBL4587325; SCHEMBL21056061; BDBM50503421]
InChI Key
UNHBZLNCSUCMET-DAXSKMNVSA-N
InChI
InChI=1S/C10H7Cl2N/c1-7(4-5-13)9-3-2-8(11)6-10(9)12/h2-4,6H,1H3/b7-4-
IUPAC Name
(Z)-3-(24-dichlorophenyl)but-2-enenitrile
CAS Number
1202041-71-1

Structure Information

Chemical Structure Visualization

SMILES Notation
2D Molecular Drawing
Carbon (C)
Hydrogen (H)
Oxygen (O)
Nitrogen (N)
Sulfur (S)
SDF

20 20 0 0 0 0 0 0 0 0999 V2000
-2.0768 -1.5278 0.2300 C 0 0 0 0 0 0 0 0 0 0 0 0
-1.4318 -0.2249 -0.1453 C 0 0 0 0 0 0 0 0 0 0 0 0
-2.1655 0.721...

Experimental Data

Activity Data

Target Ion Channel
Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2 (beta-3/N265 mutation)
Uniprot Accession Number
Function
Allosteric Modulator
Species
Rattus norvegicus (Rat)
IC50
N/A (Not available)
EC50
EC50: 103000 nM
Ki
N/A (Not available)
Kd
N/A (Not available)
Inhibition
N/A (Not available)

Experimental Conditions

pH
pH 7.4
Holding Potential
−70 mV mV
Temperature
20–24 °C
Test Method
Patch-clamping
Test Species
Not specified

Binding Information

Binding Site
Not specified
Binding Site Residue
Not specified

Disease Information

Related Disease
Not specified

References

URL
N/A (Not available)
PMID
Patent
N/A (Not available)

Computed Properties

Heavy Atom Count
13
Rotatable Bonds
1
logP
3.9203
Complexity
55.726
TPSA (Ų)
23.79
H-Bond Donors
0
H-Bond Acceptors
1
Ring Count
1
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